Molecular Nutrition

Group Head: Serge Rezzi, Ph.D. Contact


The Molecular Nutrition group aims at characterizing unmet nutritional needs in the general population as well as in specific patient groups. It leverages an in house developed nutrient profiling approach that provides a comprehensive quantitative profile of nutrient (amino acids) and micronutrient (vitamins and elements) status in biological matrices. Computational modeling techniques are used to stratify and individualize nutritional profiles to address distinctive nutritional requirements in disease conditions (inflammatory bowel disease, cancer) and nutrient deficiencies or sub-optimal levels in healthy individuals. The group investigates physiological and biochemical processes that underpin the origins and the effects of nutrient homeostatic loss at cellular and systemic levels. The understanding of these processes are translated into new concepts with enhanced bioavailability and bioefficacy of nutrients and micronutrients to guide innovation of nutrition products. Furthermore, nutrient profiling is developed in clinical settings to invent science-robust precision nutrition concepts for health maintenance and nutritional therapeutic management.

Key Goals

  • Quantify the biological variation of nutritional status in healthy and disease conditions.
  • Understand biological causes & effects of impaired nutrient homeostasis.
  • Identify proprietary nutrition concepts to maintain & correct healthy nutritional status with enhanced nutrient/micronutrient bioavailability and bioefficacy.

 

Key Publications of the Group*

Rezzi, S., Collino, S., Goulet, L., Martin, F.-P. Metabonomic approaches to nutrient metabolism and future molecular nutrition. TrAC - Trends in Analytical Chemistry, 52, 112-119, 2013.

Merrifield, C.A., Lewis, M.C., Claus, S.P., Pearce, J.T.M., Cloarec, O., Duncker, S., Heinzmann, S.S., Dumas, M.-E., Kochhar, S., Rezzi, S., Mercenier, A., Nicholson, J.K., Bailey, M., Holmes, E. Weaning diet induces sustained metabolic phenotype shift in the pig and influences host response to Bifidobacterium lactis NCC2818. Gut, 62, 842-851, 2013.

Collino, S., Montoliu, I., Martin, F.-P., Scherer, M., Mari, D., Salvioli, S., Bucci, L., Ostan, R., Monti, D., Biagi, E., Brigidi, P., Franceschi, C., Rezzi, S. Metabolic Signatures of Extreme Longevity in Northern Italian Centenarians Reveal a Complex Remodeling of Lipids, Amino Acids, and Gut Microbiota Metabolism. PLoS ONE, 8, e56564, 2013.

Alonso, C., Guilarte, M., Vicario, M., Ramos, L., Ramadan, Z., Antolín, M., Martínez, C., Rezzi, S., Saperas, E., Kochhar, S., Santos, J., Malagelada, J.R. Maladaptive Intestinal Epithelial Responses to Life Stress May Predispose Healthy Women to Gut Mucosal Inflammation. Gastroenterology, 135, 163-72, 2008.

Rezzi, S., Ramadan, Z., Martin, F.-P.J., Fay, L.B., Van Bladeren, P., Lindon, J.C., Nicholson, J.K., Kochhar, S. Human metabolic phenotypes link directly to specific dietary preferences in healthy individuals. Journal of Proteome Research, 6, 4469-77, 2007.

Rezzi, S., Ramadan, Z., Fay, L.B., Kochhar, S. Nutritional metabonomics: Applications and perspectives. Journal of Proteome Research, 6, 513-25, 2007.

*Some of these publications were done before the scientist/s joined the Nestlé Institute of Health Sciences