Stem Cells

Team Leader: Marine Kraus Ph.D. Contact

The aim of the Stem Cell group is to develop models of cellular and tissue systems involved in chronic diseases. The scientific approach is based on the creation of human cell-based models that take into account genetic and lifestyle differences between health and disease groups. Through an integrated systems approach, the stem cell group will focus on different functional metabolic states and molecular pathways relevant in metabolic, brain, aging and gastrointestinal health.

Key Goals

  • Discover potential new interventions and targets to improve cell function relevant for Metabolic Health, Cognitive Health and Ageing.
  • Gain key molecular insights into the control of cell differentiation.
  • Develop biological models by taking into account differences between patient groups and the genomic diversity of human beings.

 

Key Publications of the Group*

Eunyoung Choi, Marine R-C. Kraus, Laurence A. Lemaire, Momoko Yoshimoto, Sasidhar Vemula, Leah A. Potter, Elisabetta Manduchi, Christian J. Stoeckert Jr., Anne Grapin-Botton, Mark A. Magnuson.  Lineage-specific expression of Sox17 in specifying progenitor cell fate during mouse embryogenesis. Stem Cells, Oct 30, (10):2297-308, 2012.

Kraus MR and Grapin-Botton A. Patterning and shaping the endoderm in vivo and in culture. Curr Opin Genet Dev, Aug 22, (4):347-53, 2012.

Schwenter F., Zarei S., Luy P., Padrun V., Bouche N., Lee J.S., Mulligan R.C., Morel P., Mach N.  Cell encapsulation technology as a novel strategy for human anti-tumor immunotherapy. Cancer Gene Ther, Aug 18, (8): 553-62, 2011.

Baetge E.E. Production of beta-cells from human embryonic stem cells. Diabetes Obes. Metab. 10, Suppl 4: 186-194, 2008.

Kroon E., Martinson L.A., Kadoya K., Bang A.G., Kelly O.G., Eliazer S., Young H., Richardson M., Smart N.G., Cunningham J., Agulnick A.D., D'Amour K.A., Carpenter M.K., Baetge E.E.  Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol, 26 (4): 443-452, 2008.

McLean A.B., D'Amour K.A., Jones K.L., Krishnamoorthy M., Kulik M.J., Reynolds D.M., Sheppard A.M., Liu H., Xu Y., Baetge E.E., Dalton S. Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed. Stem Cells, 25 (1): 29-38, 2007.

 

*Some of these publications were done before the scientist/s joined the Nestlé Institute of Health Sciences