Device Engineering

Group Head: Nicolas Bouche Contact


The Device Engineering group aims to develop bioactive devices integrating state of the art technologies in material science, cell engineering, micromechanics and microelectronics. Today, we focus our research and our development in two main areas, cell encapsulation technology and diagnostic devices.

The different projects conducted by our group involve strong multidisciplinary collaborations within the institute as well as with external companies and academic labs.

Key Goals

  • To develop and produce cell encapsulation devices for generating and optimizing new human cellular models of health and disease.
  • To develop and produce new device solutions for Metabolic Health studies and early stage diagnostics.
  • To collaborate with Nestlé global R&D on the development of new delivery system solutions for personalized nutrition.

 

Key Publications of the Group*

Boss C, De Marchi U, Hermant A, Conrad M1, Sizzano F, Palini A, Wiederkehr A, Bouche N. Encapsulation of Insulin-Secreting Cells Expressing a Genetically Encoded Fluorescent Calcium Indicator for Cell-Based Sensing In Vivo. Advanced Healthcare Material 2016 Dec 20.

Rezzi S, Solari S, Bouche N, Baetge EE. The Scientific Challenge of Expanding the Frontiers of Nutrition. Nestle Nutr Inst Workshop Ser. 2016; 84:111-9.

Boss C., Meurville E., Sallese J.M., Ryser P.; J. Size-selective diffusion in nanoporous alumina membranes for a glucose affinity sensor. Membr. Sci. May, 401-402:217-221, 2012.

Schwenter F., Zarei S., Luy P., Padrun V., Bouche N., Lee J.S., Mulligan R.C., Morel P., Mach N. Cell encapsulation technology as a novel strategy for human anti-tumor immunotherapy. Cancer Gene Ther, Aug, 18(8): 553-62, 2011.

Boss C., Meurville E., Sallese J.M., Ryser P. A viscosity-dependent affinity sensor for continuous monitoring of glucose in biological fluids. Biosens. Bioelectron. Dec, 30(1): 223-228, 2011.

Kroon E., Martinson L.A., Kadoya K., Bang A.G., Kelly O.G., Eliazer S., Young H., Richardson M., Smart N.G., Cunningham J., Agulnick A.D., D'Amour K.A., Carpenter M.K., Baetge E.E. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol, Apr, 26(4): 443-52. Epub 2008 Feb 20, 2008.

*Some of these publications were done before the scientist/s joined the Nestlé Institute of Health Sciences