Group Head: Patrick Descombes, Ph.D. Contact
The aim of the Functional Genomics core is to deliver and advance genomics solutions in support of the Nestlé R&D missions.
Our infrastructure includes platforms for high throughput screening/discovery (second and third generation sequencers and microarrays) and also for validation (qPCR, nanoString nCounter) for both DNA- and RNA-based applications. We provide support on experimental design and data analysis and along with the NIHS Molecular Biomarker and the BioSystems Informatics cores we enable systems approaches in a variety of research programs.
- Deliver cutting edge genomics solutions in support of Nestlé R&D projects, using sequencing and microarray technologies.
- Advance our understanding on the molecular basis of Metabolic, Gastrointestinal and Brain Health by generating and analyzing high-throughput genomics data.
- Deliver sequencing and de novo genome assembly projects for microbiome and bacterial genomics research programs.
- Develop novel laboratory and computational methodology to improve the quality of the derived genomic information.
Key Publications of the Group*
Group Head: Martin Kussmann, Ph.D. Contact
Sebastiano Collino, Ph.D. (Metabonomics) Contact
Loic Dayon, Ph.D. (Proteomics) Contact
Mojgan Masoodi, Ph.D. (Lipidomics) Contact
India Severin, Ph.D. (Diagnostics) Contact
The overarching mission of the Molecular Biomarkers Core is molecular phenotyping in brain, metabolic and gastrointestinal health/disease conditions. This is a bottom-up clinical omics approach, which complements and enhances the classical clinical phenotyping, such as blood chemistry and body composition. We achieve this by developing and deploying a multitude of omics technologies and molecular analytics, such as proteomics, metabonomics, and lipidomics, and by translating these omic signatures into diagnostics in humans.
- Deliver a molecular systems-level view on longitudinal intervention studies in humans.
- Deliver the science for Nestlé Health Science (NHS) innovation in targeted nutrition and diagnostics for the NHS platforms Vital Support and Gastrointestinal Health.
- Pursue our group’s program on Omics in Ageing, Gastrointestinal, Brain and Metabolic Health with a focus on understanding human longevity, frailty, IBD and juvenile diabetes.
- Develop and implement cutting-edge omics and molecular analytics, based on mass spectrometry, NMR spectroscopy, ELISA technology and robotics.
- Support NIHS’ molecular biology program on stem cells, circadian biology, mitochondrial function and muscle health with proteomics.
- Provide omics support and scientific insights to NHS’, NRC’s and NN’s clinical studies.
Key Publications of the Group
* These publications refers to work done by the scientist/s prior to joining the Nestlé Institute of Health Sciences